Allogeneic Stem Cell Transplant

An allogeneic stem-cell transplant utilizes good blood stem cells donated by an individual donor to repair damaged or diseased bone marrow. A stem cell transplant that is allogeneic is also known as an allogeneic bone Marrow Transplant.

A donor could be a friend, a family member, or someone else you’ve never met. These blood stem cells utilized in an allogeneic stem cell transplant may be:

  • Collecting blood from donors
  • Collecting bone marrow inside a donor’s hipbone
  • The blood sample was taken from an umbilical cord donated

Before you undergo an allogeneic stem cell transplant you’ll receive high doses of radiation or chemotherapy to destroy the cells that are diseased to prepare your body to receive the transplanted cells.

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What’s the reason for it?

An allogeneic stem-cell transplant could be a viable alternative for those suffering from various cancerous and noncancerous conditions, including:

  • Acute leukemia
  • Adrenoleukodystrophy
  • Aplastic anemia
  • Bone marrow dysfunction syndromes
  • Chronic leukemia
  • Hemoglobinopathies
  • Hodgkin’s lymphoma
  • Immune deficiencies
  • Genetically-predisposition metabolic errors
  • Multiple myeloma
  • Myelodysplastic syndromes
  • Neuroblastoma
  • Non-Hodgkin’s Lymphoma
  • Plasma cell disorders
  • POEMS syndrome
  • Primary amyloidosis

What can you be prepared to

An allogeneic stem-cell transplant requires:

  • Receiving high doses of chemotherapy (conditioning). During the process of conditioning, you’ll receive large doses of radiation therapy. Or chemotherapy to destroy your cancerous cells. The type of treatment you’ll receive is contingent on the condition of your cancer and the particular circumstances.

    The cancer treatments that are used during the conditioning process have the potential to cause bad side effects. Discuss with your physician the potential side effects you could anticipate from your treatment.

  • Injecting stem cells. Stem cells from donors are infiltrated into your bloodstream, which will then move into your bone marrow to begin to produce the new cells in your blood.
  • You will continue to receive constant medical care. After your transplant, your medical team will need to watch you closely to look for signs of any complications. There may be some time either in the hospital or nearby. You should expect to attend regular tests of your blood and appointments to observe your body’s response to the new organ.

It takes several weeks for donor cells to be absorbed into the bone marrow. And then begin creating new cells. It is possible to receive blood transfusions until bone marrow heals.

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