While it is unclear if either drug is better than the other for the treatment of excessive sleepiness, both drugs improve wakefulness in patients with this condition. Armodafinil has longer half-life, which may be beneficial for patients with this disorder. Furthermore, the drug has better side effects. This article will discuss the pros and cons of each drug. Read on to learn more.
Armodafinil has longer half-life than modafinil
The U.S. Department of Justice classified both armodafinil and modafinil as Schedule IV controlled substances. While they have a low potential for abuse, these drugs do have similarities to other drugs, including amphetamines. In addition, they both have long half-lives and may lead to dependence. In fact, modafinil’s longer half-life makes it an attractive candidate for the treatment of excessive sleepiness.
The FDA has approved armodafinil (Waklert 150) for the treatment of excessive sleepy behavior in patients with narcolepsy, shift work disorder, and OSAHS. While long-term efficacy of armodafinil is not known, physicians should periodically evaluate it for the treatment of patients with ES. While the FDA doesn’t regulate off-label use, the Center for Medication Safety (CMS) provides guidelines for its use.
The two medications are nearly identical. Modafinil has a faster onset of action, while armodafinil has a longer half-life. Armodafinil also remains in the bloodstream for longer, which could mean a more effective wakefulness effect. A study conducted in humans has shown that both medications are effective in treating excessive sleepiness, but some patients experience more benefits with armodafinil than with modafinil.
It improves wakefulness in patients with excessive sleepiness
The drug, armodafinil, improves wakefulness in patients with excessive sleepy periods. The drug has been approved to treat three conditions – narcolepsy (excessive sleepiness during daytime), shift-work sleep disorder (excessive sleepiness during scheduled waking hours), and obstructive sleep apnea/hypopnea syndrome (short periods of inadequate sleep during the night). Armodafinil is a member of a class of drugs known as wakefulness-promoting agents, which are approve for treating these diseases.
To assess its efficacy, researchers analyzed studies comparing armodafinil with a placebo. Included studies required the use of a standardized, validated measurement of daytime sleepiness. This measurement includes the Maintenance of Wakefulness Test, a measure of objective wakefulness and the ability to resist sleepiness, and the Multiple Sleep Latency Test, which measures sleepiness in a multiple-dose comparison trial. Moreover, the study also examined the effect of armodafinil on subjective sleepiness, ECG changes, and the incidence of adverse events.
The 12-week results of a study involving a large number of patients with narcolepsy and OSA showed that armodafinil can improve wakefulness in patients suffering from these conditions. The drug improved patient-reported wakefulness and improved the overall condition of patients with narcolepsy and OSA. The findings were comparable to those of studies with shorter follow-up periods. The drug was sponsore by the pharmaceutical company Cephalon, Inc. Moreover, Dr. Schwartz has consulted with several pharmaceutical companies.
It has better side effects than modafinil
In the United States, there are two medications available to treat excessive sleepiness: armodafinil and modafinil. Both drugs are approve by the FDA for this purpose. They are similar in the way they work, inhibiting dopamine reuptake in the brain, and improve wakefulness and reduce excessive sleepiness. Armodafinil has better side effects than modafinil, but the effectiveness of each is still not clear.
However, while armodafinil does help you stay awake and alert, it is not a replacement for sleeping enough. You must still get enough sleep and use breathing devices prescribed by your doctor. It is not known whether armodafinil can cause euphoria, and it is a Schedule IV drug. As such, it is important to follow the instructions carefully.
Modafinil (Modalert 200) comes in tablet form. The dosage is typically one tablet per day, taken with or without food. People suffering from shift work sleep disorder will likely take the drug in the morning, one hour before their shift begins. If you can’t get enough sleep with the dose, you should take it at the same time each day. If your schedule is unpredictable, it is best to discuss this with your doctor.